ICP-mass spectrometry in the biomedical sciences: pushing the boundaries of the application range

On the evening of Tuesday 29 April the section welcomed Professor Frank Vanhaecke from Ghent University to talk about ‘ICP-mass spectrometry in the biomedical sciences: pushing the boundaries of the application range’. Frank received the Royal Society of Chemistry’s prestigious ‘Theophilus Redwood award’ in 2023 for outstanding contributions to the chemical sciences in the area of analytical chemistry. 

Frank's talk discussed recently developed analytical methodology including the use of laser ablation – ICP-MS to reveal the distribution of (trace) elements across biological tissues, the determination of metal contents in individual cells and the use of metal isotope ratios for diagnostic and prognostic purposes.

Inductively coupled plasma-mass spectrometry (ICP-MS) is the most powerful tool for trace element analysis, as a result of which it is widely used in many application areas, including clinical analysis. While in clinical analysis, determination of essential and non-essential (toxic) elements in body fluids and tissues is considered a routine application, other approaches have not reached that status yet, despite their added value.

Frank showed how through the use of laser ablation (LA) as a means of sample introduction, a thin section of tissue can be interrogated point-by-point to reveal the distribution of targeted elements in a quantitative manner. Moreover, when combining LA with an ICP-MS unit equipped with a time-of-flight (ToF) mass analyser, a nearly complete elemental mass spectrum is available for every pixel on the tissue “map”.

The detection power of ICP-MS instrumentation has meanwhile been enhanced to such an extent that it also allows quantification of the content of exo- and endogenous elements in individual cells, using either traditional pneumatic nebulization or laser ablation as a means of sample introduction.

In addition, Frank showed how high-precision isotopic analysis of essential mineral elements can provide insights into biochemical processes and diagnostic/prognostic information, as isotope ratios can pick up on metabolic changes with higher sensitivity than element concentrations can and/or provide information that is not embedded in the element concentrations.

The added value of these more novel approaches was illustrated by discussing the results of a number of interdisciplinary research projects carried out at Frank’s labs in Ghent.

A video of Frank's presentation is embedded below or can be viewed on the RSC Belgium dedicated YouTube channel.

About Frank

Frank Vanhaecke is Senior Full Professor in Analytical Chemistry at Ghent University, where he also leads the Atomic & Mass Spectrometry  (A&MS) research group that specialises in the determination, speciation and isotopic analysis of (ultra)trace elements via ICP-MS. His group studies fundamental aspects of the technique and develops methods for solving challenging scientific problems in interdisciplinary contexts. Frank is (co)author of more than 500 papers and the work of his has team received a number of prestigious awards, including the RSC’s ‘Theophilus Redwood award’ in 2023.