The Magic of Miniature Molecular Machines

On the evening of Thursday 24 November RSC Belgium welcomed back Professor David Leigh from University of Manchester to talk about ‘Making the tiniest Machines’ with some extraordinary chemistry and also a few marvellous magic tricks! David is not only a skilled research leader and presenter but also a member of his local Magic Circle so we were treated to a highly informative and entertaining evening. The talk was hosted at the British School of Brussels in Tervuren and was also online.

According to the 2016 Nobel Prize in Chemistry Committee “We are at the dawn of a new industrial revolution of the twenty-first century, and the future will show how molecular machinery can become an integral part of our lives. The advances made have also led to the first steps towards creating truly programmable machines, and it can be envisaged that molecular robotics will be one of the next major scientific areas.”

In his highly entertaining talk David took us through much of the research that led to that statement and the award of the Chemistry Nobel Prize in 2016 to Jean-Pierre Sauvage, Sir Fraser Stoddart and Ben Feringa "for the design and synthesis of molecular machines". 

Molecular motion

In recent years, some of the first examples of synthetic molecular level machines and motors—all be they primitive by biological standards—have been developed. These molecules are often best designed to work through statistical mechanisms, rectifying random thermal motion through ratchet mechanisms in a manner reminiscent of Maxwell’s Demon. The first programmable systems have been introduced: the forerunners of a new technological era of molecular robotics.

Perhaps the best way to appreciate the technological potential of controlled molecular-level motion is to recognise that nanomotors and molecular-level machines lie at the heart of every significant biological process. Over billions of years of evolution Nature has not repeatedly chosen this solution for achieving complex task performance without good reason. In stark contrast to biology, none of mankind’s fantastic myriad of present day technologies exploit controlled molecular-level motion in any way at all: every catalyst, every material, every plastic, every pharmaceutical, every chemical reagent, all function exclusively through their static or equilibrium dynamic properties. When we learn how to build artificial structures that can control and exploit molecular level motion, and interface their effects directly with other molecular-level substructures and the outside world, it will potentially impact on every aspect of functional molecule and materials design. An improved understanding of physics and biology will surely follow.

You can find out much more about David’s research group and their work (including the recent ‘Tape reading rachet’ paper in Nature and numerous informative video) on their dedicated website. And you can also view a pdf version of David's presentation here.