Memorial Symposium for Prof Istvan Marko

On 12 and 13 September 2019 RSC Belgium was proud to sponsor a memorial symposium for our good friend and supporter Professor Istvan Marko at the Universite Catholique de Louvain (UCLouvain) in Louvain-La-Neuve. Presentations at the symposium entitled 'Organic Chemistry and The Synthesis of Complex Molecules - A tribute to István Marko' featured contributions from Istvan's many friends and colleagues including two Nobel Prize winners. It was followed by a reception and a dinner on Friday evening.

Istvan E Marko was born in Hungary in 1956 but his family fled the Soviet invasion of that year and settled in Belgium. After schooling in Wavre, István studied for a Licence en Sciences Chimiques at UCLouvain (Belgium) from 1974 to 1978 and then obtained his PhD in 1983 under the supervision of Professor L. Ghosez on the 'Semi-synthesis of Tricyclic Penicillins'. Between 1983 and 1985 he undertook postdoctoral studies in Ghosez's group on Intramolecular Keteniminium Cycloadditions: A New Route Towards Prostaglandins.

Then between 1985 and 1987, he moved to Burlington (University of Vermont, Vermont, USA), working in the group of Professor M.E Kuehne ("Biomimetic Total Synthesis of Monoterpene Indole Alkaloids and Binary Vinca Alkaloids") before joining in 1987 the research group of professor Barry Sharpless (MIT, Massachusetts, USA) working on the Catalytic Asymmetric Osmylation of Olefins. Barry Sharpless later won the 2001 Nobel Prize for Chemistry for his work on Olefins and sent a video contribution to the symposium. Istvan also collaborated with 2016 Nobel Prize winner Ben Feringa who gave an outstanding presentation at the symposium (See photo below).

In 1988, Istvan decided to move back to Europe to take up a lecturer position in the University of Sheffield (United Kingdom), where he stayed for 5 years. In 1993 he had the opportunity to come back to his alma mater, where  he was in charge of the Laboratoire de Chimie Organique et Médicinale for 24 years until his untimely death in 2017.

As a professor, Istvan gave courses to bachelor's and master's students of chemistry and bio-engineering (Organic chemistry, Medicinal chemistry, Applied organic chemistry, Biosynthesis and total synthesis of natural products and Industrial chemistry…).

The main research areas in his laboratory included: Short, efficient and stereocontrolled total synthesis of natural products; Extraction, purification and structure identification of novel natural products; Development of new methodologies based on multiple bonds and ring formation; Asymmetric catalysis with and without metals; New organometallic reagents; Anionic polycyclisation reactions; Electroorganic synthesis; Development of ecological processes; Botanochemistry; Use of enzymes and microorganisms in organic chemistry; and Use of CO2 as a basic 1- carbon unit.

In the course of his career, Professor Markó supervised 39 post-docs, 66 PhD students, 92 master's students and 58 bachelor's students.

In January 1995, a group of young chemists including István Markó, launched the European Chemical Society (ECS), which at its inception, anticipated working together with the existing national chemical societies to promote chemistry at the European level. 

He was the author of over 250 publications, more than 200 of them in refereed journals, 19 patents and 16 reviews for books, as well as 38 articles in Belgian newspapers on "Chemistry in our Society". He delivered more than 20 general public lectures on "the key-role of chemistry in our modern society" and gave more than 350 conferences worldwide.

István regularly took part in television broadcasts (RTBF and RTLtvi) to popularise science in order

to make it more accessible, notably in collaboration with RSC Belgium, in order to encourage younger pupils to get excited about science, and in particular Chemistry. He was particularly active, together with his faithful technician Fabio Lucaccioni, in performing chemistry shows for schools.

Professor Marko was able to generate the desire to do chemistry among many students, even those outside of organic chemistry. We are proud to salute a truly great Scientist, Professor, Mentor and Friend! Thank you Istvan!

You can access Istvan's full biography here and download a commemorative booklet produced for the symposium here.

Iron Man

On the evening of 18 November 2016 RSC Belgium members and friends enjoyed a 'A Journey through the World of Iron' with our recent past Chairman Prof Bob Crichton. This special public lecture was part of a two-day symposium on the role of iron in biochemical and biomedical environments organised to celebrate Prof Crichton's significant contributions to this field. The lecture was followed by a RSC Belgium sponsored reception in Bob's honour.

The venue for our sponsored lecture was Theatre Lavo 51 in the Lavoisier Building at the Universite Catholique de Louvain in Louvain-la-Neuve and celebrated 50 years of research into the biochemistry and metabolism of metalloproteins and also marked the 75th birthday of the speaker, UCLouvain's Emeritus Professor, and ex-RSC Belgium Chairman, Robert R. Crichton (below).

During the Symposium, world experts in the biochemistry and metabolism of metalloproteins, especially iron-containing proteins, delivered keynote lectures on their most recent achievements in this area. The lectures presented biochemical studies of iron metabolism, novel therapeutic opportunities and diagnostics, the search for new metal chelators and their crucial importance, together with the results of worldwide research on inflammation and neurological disorders such as Parkinson’s disease. Metalloproteins, especially iron-containing proteins, play a crucial role in numerous diseases, including cancer.

Celebration
The symposium and public lecture enabled us to celebrate the achievements of Prof Bob Crichton who was appointed as a professor of biochemistry at the Université catholique de Louvain in Louvain-la-Neuve in 1973 and introduced biochemistry as an mandatory part of the teaching of all chemists at the university. Bob's achievements in the biochemistry of iron proteins have been recognised at international level and he is worldwide leading figure in this important area of science.

After the public lecture an excellent reception was held including a special cake to celebrate Bob's birthday. Bob's long-time colleague at UCLouvain, Prof Istvan Marko, spoke very warmly of Bob's achievements to much applause.

Cafe Chimique on Climate Change 2015

27 January saw RSC Belgium's first event of 2015: a Cafe Chimique on Climate Change at the Auderghem Cultural Centre. A large and lively audience of RSC members and the general public listened to brief opening remarks from our two speakers - Prof Ted Shepherd of Reading University and Prof Istvan Marko - before we launched into an informed audience-led debate.

Climate change and its consequences are rarely out of the news and the RSC has recently issued a statement on climate change and the role for chemistry in its mitigation as part of its new ‘Global Challenges' initiative. So our Cafe Chimique debate was timely and provoked a large number of questions.

The speakers were introduced by new section Chairman Tim Reynolds (second right above). Prof Ted Shepherd (right) is the inaugural Grantham Professor of Climate Science at the Department of Meteorology at Reading University of Reading and has led scientific assessments of both climate (IPCC) and stratospheric ozone (WMO/UNEP). He has also worked in the World Climate Research Programme.

Prof Istvan Marko (left above) leads the Laboratory of Organic and Medicinal Chemistry at the Universite Catholique de Louvain and presented a sceptical view on climate change. The debate itself was moderated by Prof Bob Crichton (second left above).

The discussion ranged over many aspects of the science of climate change from extreme weather events to chaos theory. To follow the arguments outlined you can read a short summary of ideas from Ted Shepherd here and follow Istvan Marko's thoughts via an interview (in French) with La Libre from 2014 or get a copy of the climate-sceptic book 'Climat: 15 vérités qui dérangent' (also in French) which Istvan edited.

Feedback from the audience after the debate indicated, once again, that the Cafe Chimique format is a winner providing a great format for debate in an informal environment.

Students Open-mouthed at Chemistry Spectacular

Students from four schools in and around Brussels were left open-mouthed as Prof István Markó and his assistant Fabio Lucaccioni performed their chemistry demonstration lecture “Chemistry and Energy – a Tasty Marriage” at the Université Catholique de Louvain (UCL) site in Woluwe, Brussels on Tuesday March 20th. Two lectures were organised on the day by the RSC Belgium Section in cooperation with Scienceinfuse based at the UCL main campus at Louvain-la-Neuve.

The students, from St. Johns International School, Waterloo, the Verseau International School at Bierges, the Institut Maris Stella at Laeken and the European School Brussels II at Woluwe watched enthralled as Prof. Markó worked through over an hour of about 20 reactions involving flames, colour changes and explosions.


Following Prof. Markó’s advice the students kept their mouths open to equalise the pressure in their ears during the more substantial bangs. A volcano spluttered, photo flash bulbs were simulated, the heat from a ball of flame caused by burning hydrogen in a balloon was felt by the students in the front rows (see above), and a black serpent rose out of a beaker containing only sugar and battery acid. The students oohed and aah’d as blue luminescence spread downwards in a glass tube demonstrating energy generated in a cold reaction.

Enthusiastic response
Prof. Markó engaged his audience with commentary on the chemistry behind the reactions, and his steady repartee – untrammelled by current notions of political correctness – aimed to challenge their ideas and make them think ‘outside the box’. By the end of the lecture though, he had smoke coming out of his nostrils - from eating a Belgian waffle dipped in liquid nitrogen!

After the event, one teacher commented: “Our students were full of enthusiasm and excitement when they got back to school and enjoyed every aspect of the lecture”.

The demo lecture was repeated to a French-speaking schools audience at UCL at Louvain-la-Neuve on Thursday March 22nd in the afternoon and to a public audience on that evening. On both occasions the 500 capacity auditorium was packed. The total audience for all four shows was in excess of 1200.

TOTB cup presented
At the start of the afternoon lecture at Woluwe the winning team in this year’s RSC Belgium local ‘national’ eliminator of the RSC Top of the Bench (TOTB) Competition was presented with the Keith Price Cup. The winning team from European School Brussels II at Woluwe are pictured below with their teacher Julie Deegan and RSC Belgium Section Chairman Prof. Bob Crichton.


The Woluwe team will represent RSC Belgium at the RSC UK final of TOTB at Imperial College London that takes place on Saturday 31 March. We wish the team good luck for the competition and will report on how they get on in London.

The RSC Belgium TOTB Cup has renamed as the Keith Price Cup last year in honour of our first Chairman and principal "founding father" of the section.

A complete list of the experiments performed during our 2012 demonstration lectures is available on request from RSC Belgium’s Schools Coordinator Rita Woodward.