Shape and Form in Biology

On the evening of Thursday 14 March 2019, new section chairman Prof Bob Crichton gave the  opening talk of our 2019 programme with a description of the progress made in elucidating 'Shape and Form in Biology' at the British School of Brussels (BSB).

The shape and form of biological objects has long intrigued scientists, particularly in how they determine biological function. The world of structural biology has been dramatically changed in the last few years with the advent of new developments in electron microscopy and crystallography of biological macromolecules.

Bob's lecture outlined recent advances in two areas - cryo-electron microscopy (the 2017 Nobel Prize for Chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”) and the use of X-ray free electron lasers (the EUR 1.25 billion XFEL at the Deutsche Electronische Synchotron in Hamburg has just come on beam), supplementing existing synchrotron facilities for protein structure determination. This enables structure determination from nanocrystals, thereby overcoming some of the biggest hurdles of traditional crystallography (radiation damage) through the principle of diffraction-before-destruction, as well as simultaneously opening a new era of time-resolved (femtosecond) structural studies.

The section is organising a trip to the XFEL facility and the neighbouring DESY synchrotron in Hamburg on 28 June. Find out more here.

Prof Robert (Bob) Crichton has had a long and distinguished career in biochemical research. He graduated in Biochemistry from the University of Glasgow, Scotland, in the mid-sixties and after carrying out postdoctoral research at the Max Plank Institut für Biochimie in Munich, Germany, he moved to the Université Catholique de Louvain, Belgium in 1973, where he has been a professor of Biochemistry in the Department of Chemistry. His main research interests are in the inorganic biochemistry of iron and related metals and he is author of the book on iron metabolism -  'Iron Metabolism: From Molecular Mechanisms to Clinical Consequences.'

Of course, Bob has also been a mainstay of the RSC Belgium section for many years, giving one of its first ever talks and he has just started his third stint as Chairman of the section.

Iron Man

On the evening of 18 November 2016 RSC Belgium members and friends enjoyed a 'A Journey through the World of Iron' with our recent past Chairman Prof Bob Crichton. This special public lecture was part of a two-day symposium on the role of iron in biochemical and biomedical environments organised to celebrate Prof Crichton's significant contributions to this field. The lecture was followed by a RSC Belgium sponsored reception in Bob's honour.

The venue for our sponsored lecture was Theatre Lavo 51 in the Lavoisier Building at the Universite Catholique de Louvain in Louvain-la-Neuve and celebrated 50 years of research into the biochemistry and metabolism of metalloproteins and also marked the 75th birthday of the speaker, UCLouvain's Emeritus Professor, and ex-RSC Belgium Chairman, Robert R. Crichton (below).

During the Symposium, world experts in the biochemistry and metabolism of metalloproteins, especially iron-containing proteins, delivered keynote lectures on their most recent achievements in this area. The lectures presented biochemical studies of iron metabolism, novel therapeutic opportunities and diagnostics, the search for new metal chelators and their crucial importance, together with the results of worldwide research on inflammation and neurological disorders such as Parkinson’s disease. Metalloproteins, especially iron-containing proteins, play a crucial role in numerous diseases, including cancer.

Celebration
The symposium and public lecture enabled us to celebrate the achievements of Prof Bob Crichton who was appointed as a professor of biochemistry at the Université catholique de Louvain in Louvain-la-Neuve in 1973 and introduced biochemistry as an mandatory part of the teaching of all chemists at the university. Bob's achievements in the biochemistry of iron proteins have been recognised at international level and he is worldwide leading figure in this important area of science.

After the public lecture an excellent reception was held including a special cake to celebrate Bob's birthday. Bob's long-time colleague at UCLouvain, Prof Istvan Marko, spoke very warmly of Bob's achievements to much applause.

Silver Jubilee AGM Report

Les Amis Dînent restaurant in Wezembeek-Oppem was once again the location for the section's Annual General Meeting (AGM) and Annual Dinner on 16 January 2015. The 2015 Committee was elected and reports on the activities of the section in 2014 and the state of the section's finances were received. Tim Reynolds was elected as the new section chairman and Becki Scott becomes the new section secretary. Outgoing chairman Bob Crichton received a vote of thanks for his excellent leadership over the past six years. And we discovered that 2015 is the section's silver jubilee year!

Following the announcement of apologies and noting of those section members who had asked the chairman to act as their proxy during the meeting, the minutes of the previous AGM held on 17 January 2014 were reviewed and approved.

Tim Reynolds then gave the 2014 secretary's report on section activities. "2014 had been another successful and busy year for the section," he said. "During year the section had organised seven public events, a Saturday social excursion and participated in a number of other activities fulfilling our charitable objectives to provide popular (chemical) science lectures for our members and the public and raise the profile of the chemical sciences  schools."

2014 Highlights

Among highlights of the year were the Café Chimique on Energyon 27 January, Dr Hal Sosabowski’s series of demonstration lectures for schools and the public at the beginning of April, our guided walk discovering a range of former famous residents of Brussels led by Sarah Strange, Nick Lane’slecture on the origins of life and our International Year of Crystallography event with Gordon Leonard of the European Synchrotron Radiation Facility. The section had run another ‘mega’ Top of the Bench qualifier in November with 12 teams from six school. And the winning team was from a new entrant: the European School Brussels IV in Laeken. This year’s Chemical Challengecompetition also attracted increased participation with prizes given out at Nick Lane’s event in October.

Tim also noted that the first Norman Lloyd scholarship atCardiff University had been awarded in November to Ms Dale Lyons.

Financial Report

Rita Woodward presented the 2014 financial report and accounts. Rita estimated that the sections activities in 2014 has been supported by 450 adults and over 500 young people. At the beginning of the year the net assets of the society had been at an all-time high (€18600 but this included over €6300 in the Norman Lloyd fund). During 2014 the section made a net deficit of €4700 leaving us with total net assets of €7564 as of 31 December 2014. An amount much more in line with our historical level of assets.

Chairman’s Remarks

The Chairman thanked Rita and Tim for their reports and all members of the executive committee during 2014 for their hard work and support during this year and the previous five years of his chairmanship. He felt that the section now was more dynamic, had much greater reach and was doing more activities with younger audiences than ever before. He highlighted the contribution of Rita and Peter Woodward in providing the drinks and nibbles for many of the events during the year that added so much to the evening meetings.

A formal vote of thanks was made to Bob for his work and inspiration as Chairman over the past six years.

Elections

The elections for the new RSC Belgium Executive Committee saw some changes as well as continuity. Mr. Tim Reynolds was elected as Chairman, Mrs. Rita Woodward was re-elected as Treasurer, and Dr Becki Scott was elected as Secretary. Elected as members of the committees were Prof Bob Crichton, Prof Brian Sutcliffe, Dr David Terrell and Mr. John Swift. Dr Ian Carson is also an elected member of the committee in the middle of his two-year term. 

The full composition of the 2015 Executive committee can be found here. The first meeting of the new Executive will be on 19 February where co-opted members for 2015 will be confirmed.

The Treasurer expressed her gratitude to our auditor, Ralph Palim, and announced that he had agreed to be appointed as auditor for the section accounts for 2015.

David Terrell moved a vote of thanks to Tim Reynolds for his work as section secretary over the past five years.

Jubilee year!

During discussion under any other business it was realised that 2015 would be the section’s Silver Jubilee year. So we will need to think if some special events to celebrate!

Following the close of the meeting at 19:43, the 2015 Annual Dinner of the RSC Belgium section (see pictures above - courtesy of Ian Backhouse - and below - courtesy of Helen Lee) took place. The draft minutes of the 2015 AGM can be found here.

Go Becki! Go Bob!

A couple of RSC Belgium committee members are in awards mode: our Chairman Prof Bob Crichton has just won a prestigious award for one of his text books and Dr. Becki Scott is entering the 'X-Factor' of science - 'I'm a Scientist, Get me out of Here'.

Prof Crichton's award is for his tome entitled 'Biological Inorganic Chemistry - A New introduction to Molecular Structure and Function (Second Edition)' - see picture right' that has been chosen by the panel of judges as the recipient of the 2013 "Texty" Textbook Excellence Award awarded by the Text and Academic Authors Association (TAA).

The association created the Textbook Excellence Award in 1992 to recognize current textbooks and learning materials. To be nominated, a work must carry a copyright date for the previous or current year. TAA designed the award, called the Texty, because text materials did not have awards of their own. Entries are not limited to books but may include learning materials in all mediums.

The award ceremony will take place in Reno, Nevada on 22 June during the Association's 26th annual conference. Unfortunately Bob cannot be there in person to pick up the accolade.

X-factor

Meanwhile committee member Becki Scott has registered for ‘I’m a Scientist, Get me out of Here!’ - a free online event where school students get to meet and interact with scientists. The concept is a free X Factor-style competition between scientists, where the students are the judges.

Students challenge the scientists in intense, fast-paced online live 'chats'. They then ask the scientists all the questions they want to, and vote for their favourite scientist. The winning scientist wins a prize of £500 to help them communicate their work with the public.

The 2013 event will be taking place from Monday 17 to Friday 28 June. Teachers and scientists, sign up now to take part!.

Take a look at the 60 second video on the I’m a Scientist site to get a feel for the competition.