Shape and Form in Biology

On the evening of Thursday 14 March 2019, new section chairman Prof Bob Crichton gave the  opening talk of our 2019 programme with a description of the progress made in elucidating 'Shape and Form in Biology' at the British School of Brussels (BSB).

The shape and form of biological objects has long intrigued scientists, particularly in how they determine biological function. The world of structural biology has been dramatically changed in the last few years with the advent of new developments in electron microscopy and crystallography of biological macromolecules.

Bob's lecture outlined recent advances in two areas - cryo-electron microscopy (the 2017 Nobel Prize for Chemistry was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”) and the use of X-ray free electron lasers (the EUR 1.25 billion XFEL at the Deutsche Electronische Synchotron in Hamburg has just come on beam), supplementing existing synchrotron facilities for protein structure determination. This enables structure determination from nanocrystals, thereby overcoming some of the biggest hurdles of traditional crystallography (radiation damage) through the principle of diffraction-before-destruction, as well as simultaneously opening a new era of time-resolved (femtosecond) structural studies.

The section is organising a trip to the XFEL facility and the neighbouring DESY synchrotron in Hamburg on 28 June. Find out more here.

Prof Robert (Bob) Crichton has had a long and distinguished career in biochemical research. He graduated in Biochemistry from the University of Glasgow, Scotland, in the mid-sixties and after carrying out postdoctoral research at the Max Plank Institut für Biochimie in Munich, Germany, he moved to the Université Catholique de Louvain, Belgium in 1973, where he has been a professor of Biochemistry in the Department of Chemistry. His main research interests are in the inorganic biochemistry of iron and related metals and he is author of the book on iron metabolism -  'Iron Metabolism: From Molecular Mechanisms to Clinical Consequences.'

Of course, Bob has also been a mainstay of the RSC Belgium section for many years, giving one of its first ever talks and he has just started his third stint as Chairman of the section.

Iron Man

On the evening of 18 November 2016 RSC Belgium members and friends enjoyed a 'A Journey through the World of Iron' with our recent past Chairman Prof Bob Crichton. This special public lecture was part of a two-day symposium on the role of iron in biochemical and biomedical environments organised to celebrate Prof Crichton's significant contributions to this field. The lecture was followed by a RSC Belgium sponsored reception in Bob's honour.

The venue for our sponsored lecture was Theatre Lavo 51 in the Lavoisier Building at the Universite Catholique de Louvain in Louvain-la-Neuve and celebrated 50 years of research into the biochemistry and metabolism of metalloproteins and also marked the 75th birthday of the speaker, UCLouvain's Emeritus Professor, and ex-RSC Belgium Chairman, Robert R. Crichton (below).

During the Symposium, world experts in the biochemistry and metabolism of metalloproteins, especially iron-containing proteins, delivered keynote lectures on their most recent achievements in this area. The lectures presented biochemical studies of iron metabolism, novel therapeutic opportunities and diagnostics, the search for new metal chelators and their crucial importance, together with the results of worldwide research on inflammation and neurological disorders such as Parkinson’s disease. Metalloproteins, especially iron-containing proteins, play a crucial role in numerous diseases, including cancer.

Celebration
The symposium and public lecture enabled us to celebrate the achievements of Prof Bob Crichton who was appointed as a professor of biochemistry at the Université catholique de Louvain in Louvain-la-Neuve in 1973 and introduced biochemistry as an mandatory part of the teaching of all chemists at the university. Bob's achievements in the biochemistry of iron proteins have been recognised at international level and he is worldwide leading figure in this important area of science.

After the public lecture an excellent reception was held including a special cake to celebrate Bob's birthday. Bob's long-time colleague at UCLouvain, Prof Istvan Marko, spoke very warmly of Bob's achievements to much applause.